Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model
Identifieur interne : 000887 ( Main/Exploration ); précédent : 000886; suivant : 000888Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model
Auteurs : Carolina Escobedo-Martínez [Mexique] ; Silvia Laura Guzmán-Gutiérrez [Mexique] ; María Isabel Carrillo-L Pez [Mexique] ; Martha Alicia Deveze-Álvarez [Mexique] ; Alfonso Trujillo-Valdivia [Mexique] ; William Meza-Morales [Mexique] ; Raúl G. Enríquez [Mexique]Source :
- Molecules [ 1420-3049 ] ; 2019.
Abstract
The present study aims to evaluate the antiarthritic activity of diacetylcurcumin (DAC), a synthetic derivative where the free phenolic groups of curcumin are derivatized by acetylation, thereby conferring greater lipophilicity to the parent molecule and partially overcoming the limited systemic bioavailability of curcumin. Antiarthritic activity was evaluated on a Freund’s complete adjuvant (FCA)-induced murine model of arthritis. Oral administration of DAC (60 and 120 mg/kg) resulted in a significant inhibition of inflammation in the acute and chronic phases, respectively, demonstrating an improved and sustained anti-inflammatory effect, comparable to that of curcumin (150 mg/kg) in the chronic stage at a lower dose. Phenylbutazone (80 mg/kg) was used as a reference drug. The pharmacological consequence of DAC or curcumin treatment is the prevention of secondary lesions commonly associated with this biological model.
Url:
DOI: 10.3390/molecules24142643
PubMed: 31330908
PubMed Central: 6680498
Affiliations:
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CP 04510</wicri:noRegion></affiliation></author><author><name sortKey="Carrillo L Pez, Maria Isabel" sort="Carrillo L Pez, Maria Isabel" uniqKey="Carrillo L Pez M" first="María Isabel" last="Carrillo-L Pez">María Isabel Carrillo-L Pez</name><affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02643">Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato, Gto. CP 36050, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato, Gto. CP 36050</wicri:regionArea><wicri:noRegion>Gto. CP 36050</wicri:noRegion></affiliation></author><author><name sortKey="Deveze Lvarez, Martha Alicia" sort="Deveze Lvarez, Martha Alicia" uniqKey="Deveze Lvarez M" first="Martha Alicia" last="Deveze-Álvarez">Martha Alicia Deveze-Álvarez</name><affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02643">Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato, Gto. CP 36050, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato, Gto. CP 36050</wicri:regionArea><wicri:noRegion>Gto. CP 36050</wicri:noRegion></affiliation></author><author><name sortKey="Trujillo Valdivia, Alfonso" sort="Trujillo Valdivia, Alfonso" uniqKey="Trujillo Valdivia A" first="Alfonso" last="Trujillo-Valdivia">Alfonso Trujillo-Valdivia</name><affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02643">Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato, Gto. CP 36050, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato, Gto. CP 36050</wicri:regionArea><wicri:noRegion>Gto. CP 36050</wicri:noRegion></affiliation></author><author><name sortKey="Meza Morales, William" sort="Meza Morales, William" uniqKey="Meza Morales W" first="William" last="Meza-Morales">William Meza-Morales</name><affiliation wicri:level="1"><nlm:aff id="af3-molecules-24-02643">Instituto de Química, Universidad Nacional Autónoma de México, México, CDMX. CP 04510, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto de Química, Universidad Nacional Autónoma de México, México, CDMX. CP 04510</wicri:regionArea><wicri:noRegion>CDMX. CP 04510</wicri:noRegion></affiliation></author><author><name sortKey="Enriquez, Raul G" sort="Enriquez, Raul G" uniqKey="Enriquez R" first="Raúl G." last="Enríquez">Raúl G. Enríquez</name><affiliation wicri:level="1"><nlm:aff id="af3-molecules-24-02643">Instituto de Química, Universidad Nacional Autónoma de México, México, CDMX. CP 04510, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto de Química, Universidad Nacional Autónoma de México, México, CDMX. CP 04510</wicri:regionArea><wicri:noRegion>CDMX. CP 04510</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The present study aims to evaluate the antiarthritic activity of diacetylcurcumin (DAC), a synthetic derivative where the free phenolic groups of curcumin are derivatized by acetylation, thereby conferring greater lipophilicity to the parent molecule and partially overcoming the limited systemic bioavailability of curcumin. Antiarthritic activity was evaluated on a Freund’s complete adjuvant (FCA)-induced murine model of arthritis. Oral administration of DAC (60 and 120 mg/kg) resulted in a significant inhibition of inflammation in the acute and chronic phases, respectively, demonstrating an improved and sustained anti-inflammatory effect, comparable to that of curcumin (150 mg/kg) in the chronic stage at a lower dose. Phenylbutazone (80 mg/kg) was used as a reference drug. The pharmacological consequence of DAC or curcumin treatment is the prevention of secondary lesions commonly associated with this biological model.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Asteriou, E" uniqKey="Asteriou E">E. Asteriou</name></author><author><name sortKey="Gkoutzourelas, A" uniqKey="Gkoutzourelas A">A. Gkoutzourelas</name></author><author><name sortKey="Mavropoulos, A" uniqKey="Mavropoulos A">A. Mavropoulos</name></author><author><name sortKey="Katsiari, C" uniqKey="Katsiari C">C. Katsiari</name></author><author><name sortKey="Sakkas, L I" uniqKey="Sakkas L">L.I. 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Schroder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schleyerbach, R" uniqKey="Schleyerbach R">R. Schleyerbach</name></author><author><name sortKey="Wedde, H" uniqKey="Wedde H">H. Wedde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vane, J R" uniqKey="Vane J">J.R. Vane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vajragupta, O" uniqKey="Vajragupta O">O. Vajragupta</name></author><author><name sortKey="Boochoong, P" uniqKey="Boochoong P">P. Boochoong</name></author><author><name sortKey="Watanabe, H" uniqKey="Watanabe H">H. Watanabe</name></author><author><name sortKey="Tohda, M" uniqKey="Tohda M">M. Tohda</name></author><author><name sortKey="Kummasud, N" uniqKey="Kummasud N">N. Kummasud</name></author><author><name sortKey="Sumanont, Y" uniqKey="Sumanont Y">Y. Sumanont</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmermann, M" uniqKey="Zimmermann M">M. Zimmermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorke, D" uniqKey="Lorke D">D. Lorke</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Escobedo Martinez, Carolina" sort="Escobedo Martinez, Carolina" uniqKey="Escobedo Martinez C" first="Carolina" last="Escobedo-Martínez">Carolina Escobedo-Martínez</name></noRegion><name sortKey="Carrillo L Pez, Maria Isabel" sort="Carrillo L Pez, Maria Isabel" uniqKey="Carrillo L Pez M" first="María Isabel" last="Carrillo-L Pez">María Isabel Carrillo-L Pez</name><name sortKey="Deveze Lvarez, Martha Alicia" sort="Deveze Lvarez, Martha Alicia" uniqKey="Deveze Lvarez M" first="Martha Alicia" last="Deveze-Álvarez">Martha Alicia Deveze-Álvarez</name><name sortKey="Enriquez, Raul G" sort="Enriquez, Raul G" uniqKey="Enriquez R" first="Raúl G." last="Enríquez">Raúl G. Enríquez</name><name sortKey="Guzman Gutierrez, Silvia Laura" sort="Guzman Gutierrez, Silvia Laura" uniqKey="Guzman Gutierrez S" first="Silvia Laura" last="Guzmán-Gutiérrez">Silvia Laura Guzmán-Gutiérrez</name><name sortKey="Meza Morales, William" sort="Meza Morales, William" uniqKey="Meza Morales W" first="William" last="Meza-Morales">William Meza-Morales</name><name sortKey="Trujillo Valdivia, Alfonso" sort="Trujillo Valdivia, Alfonso" uniqKey="Trujillo Valdivia A" first="Alfonso" last="Trujillo-Valdivia">Alfonso Trujillo-Valdivia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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